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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX12 All Species: 22.73
Human Site: S646 Identified Species: 38.46
UniProt: Q92771 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92771 NP_004391 950 106006 S646 G G T M Q P V S N F R Q Q L L
Chimpanzee Pan troglodytes XP_520821 925 103112 S646 G G T M Q P V S D F R Q Q L L
Rhesus Macaque Macaca mulatta XP_001114477 931 104280 S627 G G T M Q P V S D F R Q Q L L
Dog Lupus familis XP_543872 907 102087 S628 G G T M Q P V S D F R E Q L L
Cat Felis silvestris
Mouse Mus musculus Q6AXC6 880 98710 S599 G G T M Q P M S D F R E Q L L
Rat Rattus norvegicus XP_001070646 845 94905 S564 G G T M Q P V S D F R E Q L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517598 930 104705 A658 G G T M Q P V A D F R E Q L L
Chicken Gallus gallus XP_416375 940 105739 A664 G G T M Q P V A D F R E Q L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007320 890 100643 A610 G G T M Q P V A D F K E Q L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569898 861 96577 K597 G G T M Q P T K E L K E Q L F
Honey Bee Apis mellifera XP_001121183 769 88327 N520 D H V I P K E N I I C N I I T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792082 780 88384 P531 I P P E H L L P I S L S K G P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P22516 861 98787 D604 L P E V P S E D I T T L S C N
Red Bread Mold Neurospora crassa A7UXD4 1073 119198 A721 S P F E D Y K A H L F P D V P
Conservation
Percent
Protein Identity: 100 94.4 92.4 78.3 N.A. 72.3 67.7 N.A. 71.3 67.7 N.A. 57.2 N.A. 37.5 36.3 N.A. 45.4
Protein Similarity: 100 95.8 94.4 85.2 N.A. 80 76.2 N.A. 81.7 80.2 N.A. 73.4 N.A. 53.6 53.7 N.A. 61
P-Site Identity: 100 93.3 93.3 86.6 N.A. 80 86.6 N.A. 80 80 N.A. 73.3 N.A. 53.3 0 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 66.6 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.2 25.9
Protein Similarity: N.A. N.A. N.A. N.A. 49.5 43.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 0
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % C
% Asp: 8 0 0 0 8 0 0 8 58 0 0 0 8 0 0 % D
% Glu: 0 0 8 15 0 0 15 0 8 0 0 50 0 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 65 8 0 0 0 8 % F
% Gly: 72 72 0 0 0 0 0 0 0 0 0 0 0 8 0 % G
% His: 0 8 0 0 8 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 8 0 0 8 0 0 0 0 22 8 0 0 8 8 0 % I
% Lys: 0 0 0 0 0 8 8 8 0 0 15 0 8 0 0 % K
% Leu: 8 0 0 0 0 8 8 0 0 15 8 8 0 72 65 % L
% Met: 0 0 0 72 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 8 0 0 8 0 0 8 % N
% Pro: 0 22 8 0 15 72 0 8 0 0 0 8 0 0 15 % P
% Gln: 0 0 0 0 72 0 0 0 0 0 0 22 72 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 58 0 0 0 0 % R
% Ser: 8 0 0 0 0 8 0 43 0 8 0 8 8 0 0 % S
% Thr: 0 0 72 0 0 0 8 0 0 8 8 0 0 0 8 % T
% Val: 0 0 8 8 0 0 58 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _